Common variants at Bin1 are associated with sporadic Alzheimer's disease in the Han Chinese population. (February 2015)

• Record Type: Journal Article
• Authors: Li, Hong-Lei; Yang, Ping; Liu, Zhi-Jun; Sun, Yi-Min; Lu, Shen-Ji; Tao, Qing-Qing; Guo, Qi-Hao; Wu, Zhi-Ying
• Is Part Of: Psychiatric genetics. Volume 25:Number 1(2015:Feb.)
• Publication Date: 2015-02
• Subjects: Mental illness -- Genetic aspects -- Periodicals; Periodicals; 616.89042
• DOI: 10.1097/YPG.0000000000000071
• Languages: English
• ISSNs: 0955-8829

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Objectives</title> <p>Recent genome-wide association studies identified bridging integrator 1 (<italic>Bin1</italic>) to be associated with sporadic Alzheimer's disease (SAD). To clarify the relevance of <italic>Bin1</italic> as a genetic determinant of AD, we analyzed its association in a Han Chinese population from the South East part of mainland China.</p> </sec> <sec> <title>Methods</title> <p>This study investigated 427 SAD patients and 451 unrelated age-matched and sex-matched healthy controls. Two single nucleotide polymorphisms (rs7561528 and rs744373) adjacent to <italic>Bin1</italic> that emerged from previous genome-wide association studies were genotyped using the MassARRAY Analyzer 4 Sequenom platform.</p> </sec> <sec> <title>Results</title> <p>As expected, the genotype distribution of rs7561528 was significantly different between the SAD group and the controls, with more AG in controls [odds ratio (OR) 0.605, 95% confidence interval (CI) 0.429–0.854, <italic>P</italic>=0.004], and the difference increased using an additive genetic model (OR 0.593, 95% CI 0.425–0.828, <italic>P</italic>=0.002). However, we did not observe a difference in the genotype distribution of the rs744373 between the SAD and the control group (OR 1.189, 95% CI 0.809–1.747, <italic>P</italic>=0.378).</p> </sec> <sec> <title>Conclusions</title> <p>To the best of our knowledge, our study is the first to confirm the association of the variant rs7561528 adjacent to <italic>Bin1</italic> with SAD in a Han Chinese Population.</p> </sec> </abstract>