Ectopic Apocrine Glands as a Predisposing Factor for Postinflammatory Medial Meatal Fibrosis. Issue 1 (January 2015) - Moser, Gerhard
Abstract Objective To illuminate pathophysiologic processes in postinflammatory medial meatal fibrosis (PMMF), a rare otologic disease of unknown etiology, which is defined by a progressive, obliterating fibrosis that affects the osseous part of the external auditory canal (EAC) exclusively. Study Design Retrospective clinical and histopathologic study. Setting Tertiary referral center. Patients Eleven patients (4 female and 7 male subjects) who underwent surgery of the bony EAC due to PMMF (13 ears operated). Methods Histologic and immunohistochemical assessment of tissue specimens obtained during surgical excision. Main Outcome Measure Detection of ectopic apocrine glands and concomitant inflammatory infiltrate within tissue harvested from the osseous EAC. Results Additionally to expected histologic findings, such as excessive fibrosis and a chronic inflammatory infiltrate, ectopic spread of apocrine glands was consistently detected in all of our patients. Conclusion Based on our findings, we suggest that an ectopic occurrence of adnexal structures within the bony EAC may predispose susceptible individuals to the development of PMMF. To avoid postoperative recurrence due to iatrogenic spread of cutaneous adnexal structures during surgery, the split-thickness skin graft should not exceed a thickness of 0.4 mm.