Fecal Microbiota Transplantation Via Nasogastric Tube for Recurrent Clostridium difficile Infection in Pediatric Patients. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Kronman, Matthew P.; Nielson, Heather J.; Adler, Amanda L.; Giefer, Matthew J.; Wahbeh, Ghassan; Singh, Namita; Zerr, Danielle M.; Suskind, David L.
• Is Part Of: Journal of pediatric gastroenterology and nutrition. Volume 60:Issue 1(2015)
• Publication Date: 2015-01
• Subjects: Children -- Nutrition -- Periodicals; Pediatric gastroenterology -- Periodicals; Infants -- Nutrition -- Periodicals; Nutrition disorders in children -- Periodicals; Child Nutrition -- Periodicals; Digestive System -- growth & development -- Periodicals; Gastrointestinal Diseases -- Periodicals; Infant Nutrition -- Periodicals; Nutrition Disorders -- Periodicals; Child; 618.923
• DOI: 10.1097/MPG.0000000000000545
• Languages: English
• ISSNs: 0277-2116

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>ABSTRACT</title> <p>Fecal microbiota transplantation (FMT) is a safe and effective therapy for adults with recurrent <italic>Clostridium difficile</italic> colitis, but data regarding FMT in children are limited and focus on colonoscopic administration of FMT. We present 10 consecutive children who received FMT via nasogastric tube for treatment of recurrent <italic>C difficile</italic> infection. Median age was 5.4 years, and 30% were receiving simultaneous immunosuppression. Median follow-up was 44 days, and 90% of patients resolved their <italic>C difficile</italic> infection; one patient relapsed 2 months later after receiving antibiotics. FMT via nasogastric tube appears safe, well tolerated, and effective in treating pediatric recurrent <italic>C difficile</italic> colitis.</p> </sec> </abstract>