Receptor for advanced glycation endproducts and progressive kidney disease. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Fukami, Kei; Taguchi, Kensei; Yamagishi, Sho-ichi; Okuda, Seiya
• Is Part Of: Current opinion in nephrology and hypertension. Volume 24:Issue 1(2015:Jan.)
• Publication Date: 2015-01
• Subjects: Hypertension -- Periodicals; Nephrology -- Periodicals; Hypertension -- Indexes; Hypertension -- Periodicals; Kidney Diseases -- Indexes; Kidney Diseases -- Periodicals; Nephrology -- Periodicals; 616.132
• DOI: 10.1097/MNH.0000000000000091
• Languages: English
• ISSNs: 1062-4821

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Purpose of review</title> <p>Receptor for advanced glycation endproducts (RAGE) is a multiligand receptor of the immunoglobulin superfamily, which binds not only to advanced glycation endproducts, but also to high-mobility group box-1, S100/calgranulins, amyloid fibrils, and lipopolysaccharide. We discuss the pathophysiological role of RAGE in both diabetic and nondiabetic progressive renal diseases, and its potential use for therapeutic interventions in these devastating disorders.</p> </sec> <sec> <title>Recent findings</title> <p>Although initial studies about RAGE focused on diabetic nephropathy, a number of recent findings have revealed that RAGE also actively participates in the pathogenesis of nondiabetic progressive renal diseases, including hypertensive nephropathy, obesity-related glomerulopathy, lupus nephritis, autosomal dominant polycystic kidney disease, renal amyloidosis, and septic acute kidney injury. Furthermore, blocking the RAGE by a neutralizing antibody or genetic deletion of RAGE was found to prevent the development and progression of various renal disorders.</p> </sec> <sec> <title>Summary</title> <p>The interaction of several RAGE ligands with RAGE plays a role in a broad range of progressive kidney diseases. The blockade of the various RAGE ligands–RAGE interactions might be a novel therapeutic strategy for preventing the development and progression of numerous progressive kidney diseases.</p> </sec> </abstract>