Epstein-Barr Virus (EBV)-positive Sporadic Burkitt Lymphoma. (February 2015)

• Record Type: Journal Article
• Authors: Satou, Akira; Asano, Naoko; Nakazawa, Atsuko; Osumi, Tomoo; Tsurusawa, Masahito; Ishiguro, Atsushi; Elsayed, Ahmed Ali; Nakamura, Naoya; Ohshima, Koichi; Kinoshita, Tomohiro; Nakamura, Shigeo
• Is Part Of: American journal of surgical pathology. Volume 39:Number 2(2015)
• Publication Date: 2015-02
• Subjects: Pathology, Surgical -- Periodicals; 617.0705
• DOI: 10.1097/PAS.0000000000000332
• Languages: English
• ISSNs: 0147-5185

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <p>Epstein-Barr virus (EBV) is detected in 20% to 30% of sporadic Burkitt lymphoma (sBL). However, only a few studies of EBV-positive (EBV<sup>+</sup>) sBL have been reported, and its characteristics still remain controversial. To highlight the features of EBV<sup>+</sup> sBL, we compared the clinicopathologic characteristics of 33 cases of EBV<sup>+</sup> and 117 cases of EBV-negative (EBV<sup>−</sup>) sBL in Japan. EBV<sup>+</sup> sBL showed significantly higher age distribution (median, 42 vs. 13 y; <italic>P</italic><0.0001) and higher frequency of patients older than 50 years (48% vs. 16%, <italic>P</italic><0.0001). We also revealed the difference of the involved sites. The EBV<sup>+</sup> group showed significantly higher incidence of involvement of tonsil (<italic>P</italic>=0.027), adrenal gland (<italic>P</italic>=0.011), and cervical lymph node (<italic>P</italic>=0.040). In addition, the EBV<sup>+</sup> group tended to have higher incidence of nodal involvement (<italic>P</italic>=0.078) and involvement of para-aorta lymph node (<italic>P</italic>=0.084) and heart (<italic>P</italic>=0.050). In contrast, the gastrointestinal tract was less frequently affected in EBV<sup>+</sup> sBL (<italic>P</italic>=0.024). In addition, the less positivity for MUM1 (<italic>P</italic>=0.020) of EBV<sup>+</sup> sBL was highlighted. These results indicate that biological behavior and pathogenesis of EBV<sup>+</sup> sBL might be different from those of EBV<sup>−</sup> sBL. Our results demonstrate that EBV<sup>+</sup> sBL has an aspect of age-related disease and is a distinct clinicopathologic subtype, which should be distinguished from EBV<sup>−</sup> sBL.</p> </sec> </abstract>