Environmentally-defined enhancer populations regulate diversity of tissue-resident macrophages. Issue 2 (February 2015)

• Record Type: Journal Article
• Authors: Bulger, Michael; Palis, James
• Is Part Of: Trends in immunology. Volume 36:Issue 2(2015)
• Page Start: 61
• Page End: 62
• Publication Date: 2015-02
• Subjects: Immunology -- Periodicals; 571.96
• DOI: 10.1016/j.it.2014.12.002
• Languages: English
• ISSNs: 1471-4906

Abstract

<abstract abstract-type="author" id="abs0005"> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <p id="spar0005">Macrophages represent a class of cells specialized for phagocytosis that occurs in multiple, phenotypically distinct populations throughout the body. Two studies published in <italic>Cell</italic> demonstrate that these phenotypic differences reflect drastic differences in the populations of enhancers that regulate transcription, and that this epigenomic diversity is, in fact, highly plastic and sensitive to environmental cues.</p> </sec> </abstract>