A novel temozolomide analog, NEO212, with enhanced activity against MGMT-positive melanoma in vitro and in vivo. Issue 2 (28th March 2015)

• Record Type: Journal Article
• Authors: Chen, Thomas C.; Cho, Hee-Yeon; Wang, Weijun; Nguyen, Jenny; Jhaveri, Niyati; Rosenstein-Sisson, Rachel; Hofman, Florence M.; Schönthal, Axel H.
• Is Part Of: Cancer letters. Volume 358:Issue 2(2015)
• Page Start: 144
• Page End: 151
• Publication Date: 2015-03-28
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2014.12.021
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">Temozolomide was modified by conjugation to perillyl alcohol.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">The resulting novel analog, NEO212, exerted superior activity against melanoma.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">NEO212 was also active against drug-resistant tumors in vivo.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">NEO212 should be developed for clinical use.</p> </list-item> </list> </p> </sec> </abstract>