Neuropilin-2 mediates lymphangiogenesis of colorectal carcinoma via a VEGFC/VEGFR3 independent signaling. Issue 2 (28th March 2015)

• Record Type: Journal Article
• Authors: Ou, Juan-Juan; Wei, Xing; Peng, Yuan; Zha, Lin; Zhou, Rong-Bin; Shi, Hang; Zhou, Qi; Liang, Hou-Jie
• Is Part Of: Cancer letters. Volume 358:Issue 2(2015)
• Page Start: 200
• Page End: 209
• Publication Date: 2015-03-28
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2014.12.046
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">NRP2 expression levels of LECs are significantly correlated with the density of tumor lymphatic vessels in CRC.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">Activation of NRP2 in LECs substantially increases their migration, sprouting, and tubulogenesis capacity.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">NRP2 activation promotes CRC lymphangiogenesis via activating integrinα9β1/FAK/Erk signaling independent of VEGF pathway.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">NRP2 is a potential therapeutic target in preventing lymphatic metastasis of CRCs.</p> </list-item> </list> </p> </sec> </abstract>