Outcomes of Primary Lymphoma of the Ocular Adnexa (Orbital Lymphoma) Treated with Radiotherapy. Issue 3 (March 2015)

• Record Type: Journal Article
• Authors: Woolf, D.K.; Kuhan, H.; Shoffren, O.; Akinnawo, E.M.; Sivagurunathan, B.; Boyce, H.; Plowman, P.N.
• Is Part Of: Clinical oncology. Volume 27:Issue 3(2015)
• Page Start: 153
• Page End: 159
• Publication Date: 2015-03
• Subjects: Oncology -- Periodicals; Tumors -- Periodicals; Cancer -- Treatment -- Periodicals; Radiotherapy -- Periodicals; Neoplasms -- Periodicals; Cancer -- Radiotherapy; Cancer -- Treatment; Oncology; Medical radiology; Radiotherapy; Tumors; Electronic journals; Periodicals; 616.994
• DOI: 10.1016/j.clon.2014.10.002
• Languages: English
• ISSNs: 0936-6555

Abstract

<abstract xml:lang="en" abstract-type="author" id="abs0010"> <title id="sectitle0010">Abstract</title> <sec> <title id="sectitle0015">Aims</title> <p id="abspara0010">Low-grade ocular adnexal lymphoma is a rare disease and often treated with local radiotherapy to varying doses. Most previously reported studies have a very heterogeneous patient population and treatments. We report the outcomes from a 10 year cohort of patients at our institution treated with primary radiation therapy.</p> </sec> <sec> <title id="sectitle0020">Materials and methods</title> <p id="abspara0015">We analysed a retrospective case series of patients with stage IE low-grade ocular adnexal lymphoma including a review of case notes, histological reports and radiotherapy charts. We assessed local and distant tumour control and relapse rates in addition to toxicity. Disease-free survival was estimated using the Kaplan–Meier method.</p> </sec> <sec> <title id="sectitle0025">Results</title> <p id="abspara0020">In total, 81 patients and 85 orbits were treated with primary radiotherapy to a median dose of 30 Gy in 15 fractions over 3 weeks. Seventy-nine per cent were treated with standard MV external beam radiotherapy to the whole orbit and 21% with a lens-sparing technique. The median follow-up was 4.4 years (range 0.2–10.4). Local control rates were 100%, with 5% of patients experiencing disease relapse elsewhere. No patients died from lymphoma. Cumulative acute toxicity rates were 51% (mainly erythema and conjunctivitis) and late toxicity rates were 8% (mainly cataract). The lens-sparing technique was associated with a significant reduction in cataract rate (<italic>P</italic> = 0.013) and an increase in acute toxicity (<italic>P</italic> < 0.001).</p> </sec> <sec> <title id="sectitle0030">Conclusions</title> <p id="abspara0025">This study has shown excellent local control rates and acceptable toxicity from the treatment of stage IE low-grade ocular adnexal lymphoma with localised radiotherapy to a median dose of 30 Gy in 15 fractions over 3 weeks.</p> </sec> </abstract>