Peri-conception parental obesity, reproductive health, and transgenerational impacts. (February 2015)

• Record Type: Journal Article
• Authors: Lane, Michelle; Zander-Fox, Deirdre L.; Robker, Rebecca L.; McPherson, Nicole O.
• Is Part Of: Trends in endocrinology and metabolism. Volume 26:Number 2(2015)
• Page Start: 84
• Page End: 90
• Publication Date: 2015-02
• Subjects: Endocrinology -- Periodicals; Metabolism -- Periodicals; Metabolism; 616.4
• DOI: 10.1016/j.tem.2014.11.005
• Languages: English
• ISSNs: 1043-2760

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Maternal obesity changes oocyte composition altering lipid content and mitochondrial function.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Maternal obesity-induced changes impact on embryo development, programming disease risk in offspring.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Paternal obesity at conception impairs the metabolic and reproductive health of the offspring through two generations.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Paternal obesity alters epigenetic marks in sperm implicating these changes in the transmission of paternal health cues to the next generation.</p> </list-item> </list> </p> </sec> </abstract>