Poly(ADP-ribose) polymerases as modulators of mitochondrial activity. (February 2015)

• Record Type: Journal Article
• Authors: Bai, Peter; Nagy, Lilla; Fodor, Tamás; Liaudet, Lucas; Pacher, Pal
• Is Part Of: Trends in endocrinology and metabolism. Volume 26:Number 2(2015)
• Page Start: 75
• Page End: 83
• Publication Date: 2015-02
• Subjects: Endocrinology -- Periodicals; Metabolism -- Periodicals; Metabolism; 616.4
• DOI: 10.1016/j.tem.2014.11.003
• Languages: English
• ISSNs: 1043-2760

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Activation of poly(ADP-ribose) polymerases-1 and -2 (PARP-1 and PARP-2) deteriorates mitochondrial activity.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">NAD⁺ and ATP degradation are not coupled to each other upon PARP activation.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">PARPs interact with transcription factors modulating mitochondrial activity.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">PARPs can be positive regulators of mitochondrial output under sublethal stress.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">PARP inhibition is an attractive target for treating mitochondrial dysfunction.</p> </list-item> </list> </p> </sec> </abstract>