Administration of standard-dose BEP regimen (bleomycin + etoposide + cisplatin) is essential for treatment of ovarian yolk sac tumour. Issue 3 (February 2015)

• Record Type: Journal Article
• Authors: Satoh, Toyomi; Aoki, Yoichi; Kasamatsu, Takahiro; Ochiai, Kazunori; Takano, Masashi; Watanabe, Yoh; Kikkawa, Fumitaka; Takeshima, Nobuhiro; Hatae, Masayuki; Yokota, Harushige; Saito, Toshiaki; Yaegashi, Nobuo; Kobayashi, Hiroaki; Baba, Tsukasa; Kodama, Shoji; Saito, Tsuyoshi; Sakuragi, Noriaki; Sumi, Toshiyuki; Kamura, Toshiharu; Yoshikawa, Hiroyuki
• Is Part Of: European journal of cancer. Volume 51:Issue 3(2015:Feb.)
• Page Start: 340
• Page End: 351
• Publication Date: 2015-02
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Cancer; Tumors; Electronic journals; Periodicals; Electronic journals; 616.994
• DOI: 10.1016/j.ejca.2014.12.004
• Languages: English
• ISSNs: 0959-8049

Abstract

<abstract xml:lang="en" abstract-type="author" id="ab010"> <title id="st105">Abstract</title> <sec> <title id="st110">Aim</title> <p id="sp0100">The aim of this study was to investigate prognostic factors, including postoperative chemotherapy regimen, for the treatment of ovarian yolk sac tumour (YST), and resulting fertility outcome.</p> </sec> <sec> <title id="st115">Methods</title> <p id="sp0105">A multi-institutional retrospective investigation was undertaken to identify patients with ovarian pure or mixed YST who were treated between 1980 and 2007. Postoperative chemotherapy regimen and other variables were assessed in univariate and multivariate analyses. Additionally, the reproductive safety of the BEP (bleomycin, etoposide and cisplatin) regimen was evaluated.</p> </sec> <sec> <title id="st120">Results</title> <p id="sp0110">There were 211 patients enrolled from 43 institutions. The BEP regimen and a non-BEP regimen were administered to 112 and 99 patients as postoperative chemotherapy, respectively. In univariate and multivariate analyses, age ⩾ 22, alpha-fetoprotein ⩾ 33, 000 ng/ml, residual tumours after surgery and non-BEP regimen were independently and significantly associated with poor overall survival (OS). BEP was significantly superior to non-BEP in 5-year OS (93.6% versus 74.6%, <italic>P </italic>= 0.0004). Reduced-dose BEP (<75% standard-dose bleomycin and < 50% etoposide dose) was significantly associated with poorer 5-year OS compared with standard-dose BEP (89.4% versus 100%, <italic>P </italic>= 0.02 and 62.5% versus 96.9%, <italic>P </italic>= 0.0002). All patients who underwent fertility-sparing surgery recovered their menstrual cycles. Sixteen of 23 patients receiving BEP (70.0%) and 13 of 17 patients receiving non-BEP (76.5%) who were nulliparous at fertility-sparing surgery and married at the time of investigation gave birth to 21 and 19 healthy children, respectively.</p> </sec> <sec> <title id="st125">Conclusions</title> <p id="sp0115">The results of the present study suggest that standard-dose BEP should be administered for ovarian YST. BEP is as safe as non-BEP for preserving reproductive function.</p> </sec> </abstract>