Compound 48/80 acts as a potent mucosal adjuvant for vaccination against Streptococcus pneumoniae infection in young mice. Issue 8 (18th February 2015)

• Record Type: Journal Article
• Authors: Zeng, Lingbin; Liu, Yusi; Wang, Hong; Liao, Pu; Song, Zhixin; Gao, Song; Wu, Yingying; Zhang, Xuemei; Yin, Yibing; Xu, Wenchun
• Is Part Of: Vaccine. Volume 33:Issue 8(2015)
• Page Start: 1008
• Page End: 1016
• Publication Date: 2015-02-18
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2015.01.013
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Immunization with C48/80 enhances and maintains antigen-specific IgG in serum of young mice.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">C48/80 helps to clear nasal pneumococcal colonization <italic>via</italic> B cells and IL-17A.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">C48/80 induces greater protection against lethal pneumococcal infection than CT.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">C48/80 is a relatively safe adjuvant for young mice.</p> </list-item> </list> </p> </sec> </abstract>