Crosstalk between bone niche and immune system: Osteoimmunology signaling as a potential target for cancer treatment. Issue 2 (February 2015)

• Record Type: Journal Article
• Authors: Criscitiello, Carmen; Viale, Giulia; Gelao, Lucia; Esposito, Angela; De Laurentiis, Michele; De Placido, Sabino; Santangelo, Michele; Goldhirsch, Aron; Curigliano, Giuseppe
• Is Part Of: Cancer treatment reviews. Volume 41:Issue 2(2015)
• Page Start: 61
• Page End: 68
• Publication Date: 2015-02
• Subjects: Cancer -- Periodicals; Cancer -- Treatment -- Periodicals; Neoplasms -- therapy -- Periodicals; Cancer -- Périodiques; Cancer -- Traitement -- Périodiques; Cancer -- Treatment; Electronic journals; Periodicals; 616.99406
• DOI: 10.1016/j.ctrv.2014.12.001
• Languages: English
• ISSNs: 0305-7372

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st045">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0095">Osteoimmunology studies the crosstalk between skeletal and immune systems.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0100">RANK/RANKL/OPG signaling is essential for osteoclastogenesis, bone remodeling, immune system development and regulation.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0105">Cancer cells evade immunosurveillance and the bone often harbors DTCs against anticancer therapy and immune response.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0110">Besides being effective in preventing and treating SREs, bisphosphonates exert direct anti-tumor effects.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0115">The molecular crosstalk between immune and skeletal systems could be targeted with new therapeutic strategies.</p> </list-item> </list> </p> </sec> </abstract>