Drug radiotherapy combinations: Review of previous failures and reasons for future optimism. Issue 2 (February 2015)

• Record Type: Journal Article
• Authors: Higgins, Geoff S.; O'Cathail, Sean M.; Muschel, Ruth J.; McKenna, W. Gillies
• Is Part Of: Cancer treatment reviews. Volume 41:Issue 2(2015)
• Page Start: 105
• Page End: 113
• Publication Date: 2015-02
• Subjects: Cancer -- Periodicals; Cancer -- Treatment -- Periodicals; Neoplasms -- therapy -- Periodicals; Cancer -- Périodiques; Cancer -- Traitement -- Périodiques; Cancer -- Treatment; Electronic journals; Periodicals; 616.99406
• DOI: 10.1016/j.ctrv.2014.12.012
• Languages: English
• ISSNs: 0305-7372

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab015"> <title id="st085">Highlights</title> <sec> <p id="sp0050"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0230">Combined chemo-radiotherapy typically improves clinical outcomes but increases side-effects.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0235">Trials with targeted radiosensitising and hypoxia modifying drugs have been disappointing.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0240">The reasons for this include a lack of biomarkers to identify those patients likely to benefit.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0245">New drug strategies to augment radiotherapy offer great cause for optimism.</p> </list-item> </list> </p> </sec> </abstract>