Regulation and function of Myb-binding protein 1A (MYBBP1A) in cellular senescence and pathogenesis of head and neck cancer. Issue 2 (28th March 2015)

• Record Type: Journal Article
• Authors: George, Babitha; Horn, Dominik; Bayo, Pilar; Zaoui, Karim; Flechtenmacher, Christa; Grabe, Niels; Plinkert, Peter; Krizhanovsky, Valery; Hess, Jochen
• Is Part Of: Cancer letters. Volume 358:Issue 2(2015)
• Page Start: 191
• Page End: 199
• Publication Date: 2015-03-28
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2014.12.042
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">This is the first finding that demonstrates loss of MYBBP1A expression in tumor cells after DNA damage-induced senescence.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">Inverse correlation between MYBBP1A and pAKT(Ser473) after DNA damage represent a pre-senescent stage.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">MYBBP1A^lowpAKT(Ser473)^high staining serves as an independent biomarker for an unfavorable clinical outcome of OPSCC patients.</p> </list-item> </list> </p> </sec> </abstract>