Baicalein upregulates DDIT4 expression which mediates mTOR inhibition and growth inhibition in cancer cells. Issue 2 (28th March 2015)

• Record Type: Journal Article
• Authors: Wang, Yujun; Han, Ernest; Xing, Quanhua; Yan, Jin; Arrington, Amanda; Wang, Charles; Tully, Dylan; Kowolik, Claudia M.; Lu, David M.; Frankel, Paul H.; Zhai, Jing; Wen, Wei; Horne, David; Yip, M.L. Richard; Yim, John H.
• Is Part Of: Cancer letters. Volume 358:Issue 2(2015)
• Page Start: 170
• Page End: 179
• Publication Date: 2015-03-28
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2014.12.033
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">Baicalein, a natural compound, causes tumor suppression of cancer cells both <italic>in vitro</italic> and <italic>in vivo</italic>.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">Baicalein upregulates <italic>DDIT4</italic> which inhibits mTOR and mediates growth inhibition.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">Baicalein is effective in chemotherapy resistant cancer cells.</p> </list-item> </list> </p> </sec> </abstract>