Host factors for retroviral integration site selection. Issue 2 (February 2015)

• Record Type: Journal Article
• Authors: Debyser, Zeger; Christ, Frauke; De Rijck, Jan; Gijsbers, Rik
• Is Part Of: Trends in biochemical sciences. Volume 40:Issue 2(2015)
• Page Start: 108
• Page End: 116
• Publication Date: 2015-02
• Subjects: Biochemistry -- Periodicals; 572
• DOI: 10.1016/j.tibs.2014.12.001
• Languages: English
• ISSNs: 0968-0004

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">LEDGF/p75 and BET are the targeting factors for lentiviral and gammaretroviral integration.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Both chromatin-readers link the fate of the provirus with the epigenetic status of the chromatin.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">LEDGINs are novel antivirals that interfere with the interaction between HIV integrase and LEDGF/p75.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Re-engineered LEDGF/p75 and BET tethers may open new avenues for safer gene therapy.</p> </list-item> </list> </p> </sec> </abstract>