The bone marrow microenvironment is a critical player in the NK cell response against acute myeloid leukaemia in vitro. Issue 2 (February 2015)

• Record Type: Journal Article
• Authors: Vasold, Jochen; Wagner, Michaela; Drolle, Heidrun; Deniffel, Christian; Kütt, Alexander; Oostendorp, Robert; Sironi, Silvia; Rieger, Christina; Fiegl, Michael
• Is Part Of: Leukemia research. Volume 39:Issue 2(2015:Feb.)
• Page Start: 257
• Page End: 262
• Publication Date: 2015-02
• Subjects: Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2014.12.001
• Languages: English
• ISSNs: 0145-2126

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">The bone marrow microenvironment creates a niche for leukemic blasts.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">This microenvironment comprises inter alia hypoxia and mesenchymal stromal cells.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Hypoxia of 1% O₂ enhances leukaemia cell lysis by NK cells.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Mesenchymal stromal cells protect leukaemia cell from NK cell mediated lysis.</p> </list-item> </list> </p> </sec> </abstract>