Live virus vaccines based on a yellow fever vaccine backbone: Standardized template with key considerations for a risk/benefit assessment. Issue 1 (1st January 2015)

• Record Type: Journal Article
• Authors: Monath, Thomas P.; Seligman, Stephen J.; Robertson, James S.; Guy, Bruno; Hayes, Edward B.; Condit, Richard C.; Excler, Jean Louis; Mac, Lisa Marie; Carbery, Baevin; Chen, Robert T.; The Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG), 4
• Is Part Of: Vaccine. Volume 33:Issue 1(2015)
• Page Start: 62
• Page End: 72
• Publication Date: 2015-01-01
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2014.10.004
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0020"> <list id="lis0010"> <list-item id="lsti0005"> <label></label> <p id="par0005">The Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG) evaluates vaccine safety.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Many recombinant viral vectored vaccines are in advanced clinical trials.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">A template is presented for evaluating live recombinant flavivirus vaccines in which genes for envelope proteins have replaced the corresponding genes in yellow fever virus vaccine.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">The template can be used as a model for other live recombinant viral vaccines.</p> </list-item> </list> </p> </sec> </abstract>