Development of a subunit vaccine containing recombinant Riemerella anatipestifer outer membrane protein A and CpG ODN adjuvant. Issue 1 (1st January 2015)

• Record Type: Journal Article
• Authors: Chu, Chun-Yen; Liu, Chia-Hui; Liou, Jhong-Jie; Lee, Jai-Wei; Cheng, Li-Ting
• Is Part Of: Vaccine. Volume 33:Issue 1(2015)
• Page Start: 92
• Page End: 99
• Publication Date: 2015-01-01
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2014.11.010
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0045"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">OmpA was combined with CpG ODN plasmids as a vaccine against <italic>R. anatipestifer</italic>.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">CpG ODN enhanced IFN-γ, IL-12 and IL-6 production by duck PBMC.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">CpG ODN helped increase antigen-specific lymphocyte population and T cell activation.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">OmpA + CpG ODN reduced pathological lesions by 90% in a challenge experiment.</p> </list-item> </list> </p> </sec> </abstract>