BCG vaccination-induced long-lasting control of Mycobacterium tuberculosis correlates with the accumulation of a novel population of CD4+IL-17+TNF+IL-2+ T cells. Issue 1 (1st January 2015)

• Record Type: Journal Article
• Authors: Cruz, Andrea; Torrado, Egídio; Carmona, Jenny; Fraga, Alexandra G.; Costa, Patrício; Rodrigues, Fernando; Appelberg, Rui; Correia-Neves, Margarida; Cooper, Andrea M.; Saraiva, Margarida; Pedrosa, Jorge; Castro, António G.
• Is Part Of: Vaccine. Volume 33:Issue 1(2015)
• Page Start: 85
• Page End: 91
• Publication Date: 2015-01-01
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2014.11.013
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0030"> <list id="lis0010"> <list-item id="lsti0005"> <label></label> <p id="par0005">Mice were vaccinated with BCG for 21 or 120 days before challenged with Mtb.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Mice challenged 120 days after BCG vaccination displayed improved control of Mtb.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">BCG-mediated control of Mtb correlates with the IL-17 response and is independent of the magnitude of the IFN-γ response in the lung.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Long-lasting control of Mtb correlates with the accumulation of CD4⁺ T cells producing IL-17, TNF and IL-2.</p> </list-item> </list> </p> </sec> </abstract>