Anti-Group B Streptococcus antibody in infants born to mothers with human immunodeficiency virus (HIV) infection. Issue 5 (29th January 2015)

• Record Type: Journal Article
• Authors: Le Doare, Kirsty; Allen, Lauren; Kampmann, Beate; Heath, Paul Trafford; Taylor, Stephen; Hesseling, Anneke C.; Gorringe, Andrew; Jones, Christine Elizabeth
• Is Part Of: Vaccine. Volume 33:Issue 5(2015)
• Page Start: 621
• Page End: 627
• Publication Date: 2015-01-29
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2014.12.025
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">HIV-infected women have lower anti-GBS surface binding antibody concentrations than uninfected controls with reduced antibody-mediated deposition of complement C3b/iC3b onto GBS bacteria.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">HIV-exposed, uninfected infants have a lower concentration of antibody binding to the surface of GBS bacteria as well as a reduction in antibody-mediated deposition of complement C3b/iC3b onto the surface of GBS strains at birth compared to HIV-unexposed infants.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">As a result, HIV-exposed uninfected infants may be at increased risk of early and late onset GBS disease compared to unexposed infants.</p> </list-item> </list> </p> </sec> </abstract>