Usefulness of low- and high-volume multiple rapid swallowing during high-resolution manometry. Issue 2 (February 2015)

• Record Type: Journal Article
• Authors: Elvevi, Alessandra; Mauro, Aurelio; Pugliese, Delia; Bravi, Ivana; Tenca, Andrea; Consonni, Dario; Conte, Dario; Penagini, Roberto
• Is Part Of: Digestive and liver disease. Volume 47:Issue 2(2015)
• Page Start: 103
• Page End: 107
• Publication Date: 2015-02
• Subjects: Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; 616.33005
• DOI: 10.1016/j.dld.2014.10.007
• Languages: English
• ISSNs: 1590-8658

Abstract

<abstract abstract-type="author" id="abs0005"> <title id="sect0005">Abstract</title> <sec> <title id="sect0010">Background</title> <p id="spar0005">It has been suggested that multiple rapid swallowing should be added to oesophageal manometry.</p> </sec> <sec> <title id="sect0015">Aim</title> <p id="spar0010">To prospectively evaluate whether 10 and 200 mL multiple rapid swallowing provide different information concerning motor function.</p> </sec> <sec> <title id="sect0020">Methods</title> <p id="spar0015">30 consecutive patients with oesophageal symptoms, 13 achalasia patients after successful pneumatic dilation and 19 healthy subjects performed eight 5 mL single swallows, two 10 mL and one 200 mL multiple rapid swallowing.</p> </sec> <sec> <title id="sect0025">Results</title> <p id="spar0020">Almost all of the healthy subjects and two-thirds of the patients with oesophageal symptoms showed motor inhibition during both 10 and 200 mL multiple rapid swallowing. The oesophago-gastric pressure gradient was significantly higher during 200 mL multiple rapid swallowing within each group (<italic>p</italic> < 0.01), and significantly higher in the achalasia patients than in the other two groups (<italic>p</italic> < 0.0001). Presence of a contraction and increased contraction strength in comparison with single swallows were both more frequent after 10 mL than after 200 mL multiple rapid swallowing in the healthy subjects and the patients (<italic>p</italic> < 0.05).</p> </sec> <sec> <title id="sect0030">Conclusion</title> <p id="spar0025">Motor inhibition could be similarly evaluated by means of 10 and 200 mL multiple rapid swallowing; 10 mL evaluated the after-contraction, whereas 200 mL multiple rapid swallowing was more valuable in identifying increased resistance to outflow.</p> </sec> </abstract>