Novel TNS3-MAP3K3 and ZFPM2-ELF5 fusion genes identified by RNA sequencing in multicystic mesothelioma with t(7;17)(p12;q23) and t(8;11)(q23;p13). Issue 2 (28th February 2015)

• Record Type: Journal Article
• Authors: Panagopoulos, Ioannis; Gorunova, Ludmila; Davidson, Ben; Heim, Sverre
• Is Part Of: Cancer letters. Volume 357:Issue 2(2015)
• Page Start: 502
• Page End: 509
• Publication Date: 2015-02-28
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2014.12.002
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">A multicystic mesothelioma had the karyotype 46, XX, t(7;17)(p13;q23), t(8;11)(q23;p13).</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">The t(7;17)(p13;q23) generated a chimeric <italic>TNS3-MAP3K3</italic> gene, which codes for a chimeric protein kinase.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">The translocation, t(8;11)(q23;p13), generated a chimeric <italic>ZFPM2-ELF5</italic> gene which codes for a chimeric transcription factor.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">The findings confirm the neoplastic nature of multicystic mesothelioma.</p> </list-item> </list> </p> </sec> </abstract>