Activation of human telomerase reverse transcriptase through gene fusion in clear cell sarcoma of the kidney. Issue 2 (28th February 2015)

• Record Type: Journal Article
• Authors: Karlsson, Jenny; Lilljebjörn, Henrik; Holmquist Mengelbier, Linda; Valind, Anders; Rissler, Marianne; Øra, Ingrid; Fioretos, Thoas; Gisselsson, David
• Is Part Of: Cancer letters. Volume 357:Issue 2(2015)
• Page Start: 498
• Page End: 501
• Publication Date: 2015-02-28
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2014.11.057
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">The first report on RNA-sequencing data of clear cell sarcoma of the kidney (CCSK).</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">A novel fusion, <italic>IRX2-TERT</italic>, was identified that lead to increased <italic>TERT</italic> expression.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">Telomerase reverse transcriptase can be activated via fusion transcripts.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">A previously published <italic>YWHAE-NUTM2B/NUTM2E</italic> fusion was found in 2/22 CCSKs.</p> </list-item> <list-item id="u0030"> <label></label> <p id="p0030">The majority of CCSKs appear to lack fusion transcripts.</p> </list-item> </list> </p> </sec> </abstract>