RNA over-editing of BLCAP contributes to hepatocarcinogenesis identified by whole-genome and transcriptome sequencing. Issue 2 (28th February 2015)

• Record Type: Journal Article
• Authors: Hu, Xueda; Wan, Shengqing; Ou, Ying; Zhou, Boping; Zhu, Jialou; Yi, Xin; Guan, Yanfang; Jia, Wenlong; Liu, Xing; Wang, Qiudao; Qi, Yao; Yuan, Qing; Huang, Wanqiu; Liao, Weijia; Wang, Yun; Zhang, Qinghua; Xiao, Huasheng; Chen, Xinchun; Huang, Jian
• Is Part Of: Cancer letters. Volume 357:Issue 2(2015)
• Page Start: 510
• Page End: 519
• Publication Date: 2015-02-28
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2014.12.006
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">There are widespread RNA editing events in the transcriptome of human liver tissue using NGS technology.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">There is differential expression of RNA editing genes in HCC compared to non tumor liver.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">BLCAP RNA over-editing contributes to hepatocarcinogenesis.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">BLCAP RNA editing can activate the Akt/mTOR signaling pathway by affecting the phosphorylation levels.</p> </list-item> </list> </p> </sec> </abstract>