Genome-wide transcriptional analyses of Chinese patients reveal cell migration is attenuated in IDH1-mutant glioblastomas. Issue 2 (28th February 2015)

• Record Type: Journal Article
• Authors: Hu, Huimin; Wang, Zheng; Liu, Yanwei; Zhang, Chuanbao; Li, Mingyang; Zhang, Wenlong; Wang, Kuanyu; Cai, Jinquan; Cheng, Wen; Huang, Hua; Jiang, Tao
• Is Part Of: Cancer letters. Volume 357:Issue 2(2015)
• Page Start: 566
• Page End: 574
• Publication Date: 2015-02-28
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2014.12.018
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010">We aimed to explore the mechanisms underlying different outcomes of IDH1 WT and IDH1 mutated glioblastomas (GBMs) through analysis of genes differential expression.</p> <p id="sp0015">New findings were as follows.</p> <p id="sp0020"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">Transcriptional differences between IDH1 mutant and wild type GBMs derived from 69 Chinese patients revealed compromised focal adhesion in IDH1 mutant GBMs.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">GBM cells stably expressing mutated IDH1 showed diminished adhesion between each other and less cell aggregation.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">The reported downstream of IDH1 and the important modulator of cell adhesion and migration, HIF1α, was found affected by IDH1 mutation.</p> </list-item> </list> </p> </sec> </abstract>