Discovery of potent 1H-imidazo[4, 5-b]pyridine-based c-Met kinase inhibitors via mechanism-directed structural optimization. Issue 3 (1st February 2015)

• Record Type: Journal Article
• Authors: An, Xiao-De; Liu, Hongyan; Xu, Zhong-Liang; Jin, Yi; Peng, Xia; Yao, Ying-Ming; Geng, Meiyu; Long, Ya-Qiu
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 3(2015)
• Page Start: 708
• Page End: 716
• Publication Date: 2015-02-01
• Subjects: Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2014.11.070
• Languages: English
• ISSNs: 0960-894X

Abstract

<abstract xml:lang="en" abstract-type="graphical" id="ab005"> <title id="st005">Graphical abstract</title> <sec> <p id="sp0005">A new class of imidazopyridine-based c-Met kinase inhibitors exhibited nanomolar inhibition against the enzyme and the growth of Met-driven EBC-1 human lung cancer cells. <fig id="f0055" position="anchor"><graphic position="anchor" xlink:href="ark:/27927/pgh3m5sgcbh" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></fig></p> </sec> </abstract>