Possible chondroprotective effect of canakinumab: An in vitro study on human osteoarthritic chondrocytes. Issue 2 (February 2015)

• Record Type: Journal Article
• Authors: Cheleschi, Sara; Cantarini, Luca; Pascarelli, Nicola Antonio; Collodel, Giulia; Lucherini, Orso Maria; Galeazzi, Mauro; Fioravanti, Antonella
• Is Part Of: Cytokine. Volume 71:Issue 2(2015)
• Page Start: 165
• Page End: 172
• Publication Date: 2015-02
• Subjects: Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2014.10.023
• Languages: English
• ISSNs: 1043-4666

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st090">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0245">Canakinumab is a human IgGκ monoclonal antibody that neutralizes the IL-1β.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0250">OA chondrocytes incubated with canakinumab alone or with TNF-α for 48 h.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0255">Canakinumab counteracts the negative effects of TNF-α on OA chondrocyte cultures.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0260">Our experiments confirmed the protective role of canakinumab.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0265">The canakinumab may have a potential chondroprotective role in OA.</p> </list-item> </list> </p> </sec> </abstract>