The effect of nitrogen containing bisphosphonates, zoledronate and alendronate, on the production of pro-angiogenic factors by osteoblastic cells. Issue 2 (February 2015)

• Record Type: Journal Article
• Authors: Ishtiaq, S.; Edwards, S.; Sankaralingam, A.; Evans, B.A.J.; Elford, C.; Frost, M.L.; Fogelman, I.; Hampson, G.
• Is Part Of: Cytokine. Volume 71:Issue 2(2015)
• Page Start: 154
• Page End: 160
• Publication Date: 2015-02
• Subjects: Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2014.10.025
• Languages: English
• ISSNs: 1043-4666

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st075">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0145">Vascular endothelial growth factor and angiopoietin-1 are pro-angiogenic factors.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0150">Bisphosphonates (BPs) suppress the osteoblastic production of the 2 angiogenic factors.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0155">Calcitriol mitigates the BP-induced inhibition of these angiogenic factors.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0160">BPs have anti-angiogenic properties.</p> </list-item> </list> </p> </sec> </abstract>