2-Methoxyestradiol inhibits bleomycin-induced systemic sclerosis through suppression of fibroblast activation. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Zhu, Lubing; Song, Yinghua; Li, Ming
• Is Part Of: Journal of dermatological science. Volume 77:Issue 1(2015:Jan.)
• Page Start: 63
• Page End: 70
• Publication Date: 2015-01
• Subjects: Dermatology -- Periodicals; Skin Diseases -- Periodicals; Dermatologie -- Périodiques; 616.5005
• DOI: 10.1016/j.jdermsci.2014.10.007
• Languages: English
• ISSNs: 0923-1811

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">2-ME reduces skin and lung fibrosis and collagen protein and mRNA level in SSc mice.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">2-ME inhibits SSc fibroblast proliferation in a dose- and time-dependent manner.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">2-ME inhibits α-SMA expression of SSc fibroblasts.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">2-ME decreases collagen production and increases its degradation in SSc fibroblasts.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">2-ME is rising as a prospective agent for control of fibrosis in SSc.</p> </list-item> </list> </p> </sec> </abstract>