Lithium inhibits palatal fusion and osteogenic differentiation in palatal shelves in vitro. Issue 3 (March 2015) - Meng, Liuyan
Highlights LiCl induces persistence of the midline epithelial seam (MES) and causes failure of palatal fusion. LiCl prevents osteogenic differentiation in palatal shelves. LiCl may activate the canonical Wnt signaling to impair the fusion of the secondary palate.