Toxicity, genotoxicity and proinflammatory effects of amorphous nanosilica in the human intestinal Caco-2 cell line. Issue 2 (March 2015)

• Record Type: Journal Article
• Authors: Tarantini, Adeline; Lanceleur, Rachelle; Mourot, Annick; Lavault, Marie -Thérèse; Casterou, Gérald; Jarry, Gérard; Hogeveen, Kevin; Fessard, Valérie
• Is Part Of: Toxicology in vitro. Volume 29:Issue 2(2015)
• Page Start: 398
• Page End: 407
• Publication Date: 2015-03
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2014.10.023
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab010"> <title id="st165">Highlights</title> <sec> <p id="sp0065"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0235">Toxic effects of silica NPs (15 and 55 nm) were investigated in Caco-2 cells.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0240">Both NPs were localized within the cytoplasm but did not enter the nucleus.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0245">15 nm but not 55 nm silica induced genotoxic and proinflammatory effects.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0250">Oxidative stress is likely to be involved in the genotoxic mechanism of action.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0255">SiO₂ NPs may induce potential adverse effects on the intestinal epithelium <italic>in vivo</italic>.</p> </list-item> </list> </p> </sec> </abstract>