In vitro safety assessment of food ingredients in canine renal proximal tubule cells. Issue 2 (March 2015)

• Record Type: Journal Article
• Authors: Koči, J.; Jeffery, B.; Riviere, J.E.; Monteiro-Riviere, N.A.
• Is Part Of: Toxicology in vitro. Volume 29:Issue 2(2015)
• Page Start: 289
• Page End: 298
• Publication Date: 2015-03
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2014.11.002
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st155">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0255"> <italic>In vivo</italic> kidney injury markers (e.g. KIM-1) are not applicable to an <italic>in vitro</italic> model</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0260">Volatile ingredients (CINA, CBO, LGO) studied are more toxic than the nephrotoxicant 4-AP</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0265">Feasibility of extrapolating data from canine cells for human toxicity studies</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0270">Lemongrass oil (LGO) induces high levels of oxidative stress represented by GSTA3</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0275">Gene relationship and TEM analyses predict the LGO-induced cellular response</p> </list-item> </list> </p> </sec> </abstract>