Activation of calcium-sensing receptor increases TRPC3/6 expression in T lymphocyte in sepsis. Issue 1 (March 2015)

• Record Type: Journal Article
• Authors: Wu, Qiu-yue; Sun, Ming-rui; Wu, Chun-li; Li, Yang; Du, Jing-jing; Zeng, Jing-ya; Bi, Hai-liang; Sun, Yi-hua
• Is Part Of: Molecular immunology. Volume 64:Issue 1(2015:Mar.)
• Page Start: 18
• Page End: 25
• Publication Date: 2015-03
• Subjects: Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2014.10.018
• Languages: English
• ISSNs: 0161-5890

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">In septic rat T lymphocytes, calcium-sensing receptor (CaSR) activation increased the expression of TRPC3 and TRPC6 proteins.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">PLC-IP₃ signaling pathway inhibitors decreased the TRPC3 and TRPC6 expressions.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">TRPC3 and TRPC6 sustained the persisted increase of intracellular [Ca²⁺]_i levels in septic rat T lymphocytes.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">CaSR and TRPCs enhanced the T lymphocytes apoptosis through PLC-IP₃ signaling pathway in septic rat.</p> </list-item> </list> </p> </sec> </abstract>