Alternative complement pathway component Factor D contributes to efficient clearance of tissue debris following acute CCl4-induced injury. Issue 1 (March 2015)

• Record Type: Journal Article
• Authors: Cresci, Gail A.; Allende, Daniela; McMullen, Megan R.; Nagy, Laura E.
• Is Part Of: Molecular immunology. Volume 64:Issue 1(2015:Mar.)
• Page Start: 9
• Page End: 17
• Publication Date: 2015-03
• Subjects: Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2014.10.017
• Languages: English
• ISSNs: 0161-5890

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">We examine which complement activation pathway is involved for timely liver recovery following an acute toxic injury.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">We utilized mice deficient in <italic>C1qa</italic>, <italic>C4</italic> and <italic>Factor D</italic>, lacking the classical, classical/MBL, and alternative pathways of complement activation.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Factor D-deficient mice had worse liver injury compared to other genotypes.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Factor D-deficient mice were unable to adequately clear injured tissue.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">We demonstrate the importance of the alternative complement pathway in facilitating opsonization of damaged tissue for a timely reparative process following an acute toxic liver injury.</p> </list-item> </list> </p> </sec> </abstract>