Z-100, extracted from Mycobacterium tuberculosis strain Aoyama B, promotes TNF-α production via nucleotide-binding oligomerization domain containing 2 (Nod2)-dependent NF-κB activation in RAW264.7 cells. Issue 1 (March 2015)

• Record Type: Journal Article
• Authors: Katsunuma, Kokichi; Yoshinaga, Koji; Ohira, Yuta; Eta, Runa; Sato, Takanori; Horii, Takayuki; Tanaka, Takao; Takei, Mineo; Seto, Koichi
• Is Part Of: Molecular immunology. Volume 64:Issue 1(2015:Mar.)
• Page Start: 218
• Page End: 227
• Publication Date: 2015-03
• Subjects: Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2014.11.017
• Languages: English
• ISSNs: 0161-5890

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">TNF-α production from RAW264.7 cells was induced by Z-100 and IFN-γ stimulation.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Nod2 expression was up-regulated by IFN-γ treatment in RAW264.7 cells.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Z-100-induced TNF-α production was attenuated by Nod2 gene silencing.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Z-100 activates Nod2-dependent NF-κB signaling.</p> </list-item> </list> </p> </sec> </abstract>