Renal expression of Toll-like receptor 2 and 4: Dynamics in human allograft injury and comparison to rodents. Issue 1 (March 2015)

• Record Type: Journal Article
• Authors: Stribos, Elisabeth G.D.; van Werkhoven, Maaike B.; Poppelaars, Felix; van Goor, Harry; Olinga, Peter; van Son, Willem J.; Damman, Jeffrey; Seelen, Marc A.
• Is Part Of: Molecular immunology. Volume 64:Issue 1(2015:Mar.)
• Page Start: 82
• Page End: 89
• Publication Date: 2015-03
• Subjects: Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2014.11.003
• Languages: English
• ISSNs: 0161-5890

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">TLR2 and TLR4 expression dynamics in several human post-transplant injury biopsies.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Unique opportunity to stain healthy human living donor biopsies for TLR2 and TLR4.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Human acute rejection biopsies were characterized by TLR4⁺ infiltrating cells.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">A tubular staining was found in mouse and rat but not in human biopsies.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">Results from this study have an impact on future TLR inhibitor studies.</p> </list-item> </list> </p> </sec> </abstract>