Alantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA-MB-231 cells. Issue 1 (1st February 2015)

• Record Type: Journal Article
• Authors: Chun, Jaemoo; Li, Rui-Juan; Cheng, Mao-Sheng; Kim, Yeong Shik
• Is Part Of: Cancer letters. Volume 357:Issue 1(2015)
• Page Start: 393
• Page End: 403
• Publication Date: 2015-02-01
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2014.11.049
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">STAT3 is a transcription factor that is a potent regulator of tumorigenesis.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">Alantolactone suppresses constitutive and inducible STAT3 tyrosine phosphorylation.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">Alantolactone inhibits NF-κB translocation to the nucleus.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">Alantolactone inhibits cell migration, invasion, adhesion, and colony formation.</p> </list-item> <list-item id="u0030"> <label></label> <p id="p0030">Alantolactone inhibits the tumor growth of MDA-MB-231 xenografts in mice.</p> </list-item> </list> </p> </sec> </abstract>