Deubiquitinase OTUD5 mediates the sequential activation of PDCD5 and p53 in response to genotoxic stress. Issue 1 (1st February 2015)

• Record Type: Journal Article
• Authors: Park, Soo-Yeon; Choi, Hyo-Kyoung; Choi, Youngsok; Kwak, Sungmin; Choi, Kyung-Chul; Yoon, Ho-Geun
• Is Part Of: Cancer letters. Volume 357:Issue 1(2015)
• Page Start: 419
• Page End: 427
• Publication Date: 2015-02-01
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2014.12.005
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">OTUD5 binds to and increases the levels of PDCD5 and stabilizes PDCD5 by deubiquitinating Lys-97/98 of PDCD5.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">Both PDCD5 and OTUD5 are required for p53 activation and DNA damage response.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">PDCD5knock-down abrogates YAF2-OTUD5 network-mediated p53 activation</p> </list-item> </list> </p> </sec> </abstract>