Β-Arrestin1 promotes the self-renewal of the leukemia-initiating cell-enriched subpopulation in B-lineage acute lymphoblastic leukemia related to DNMT1 activity. Issue 1 (1st February 2015)

• Record Type: Journal Article
• Authors: Shu, Yi; Zhou, Xiaoyan; Qi, Xinkun; Liu, Shan; Li, Kang; Tan, Junjie; Liu, Zhidai; Yu, Jie; Zhang, Penghui; Zou, Lin
• Is Part Of: Cancer letters. Volume 357:Issue 1(2015)
• Page Start: 170
• Page End: 178
• Publication Date: 2015-02-01
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2014.11.025
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Hightlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">β-Arrestin1 is elevated in LICs from B-ALL.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">β-Arrestin1 enhances the self-renewal of LICs from B-ALL.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">The activity of DNMT1 is essential for the self-renewal of LICs from B-ALL.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">β-Arrestin1 promotes the activity of DNMT1, thus reduces the expression of PTEN in LICs from B-ALL.</p> </list-item> </list> </p> </sec> </abstract>