Overexpression of microRNA biogenesis machinery: Drosha, DGCR8 and Dicer in multiple sclerosis patients. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Jafari, Naser; Shaghaghi, Hassan; Mahmoodi, Davood; Shirzad, Zohreh; Alibeiki, Fatemeh; Bohlooli, Shahab; Dogaheh, Hadi Peeri
• Is Part Of: Journal of clinical neuroscience. Volume 22:Issue 1(2015:Jan.)
• Page Start: 200
• Page End: 203
• Publication Date: 2015-01
• Subjects: Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2014.06.106
• Languages: English
• ISSNs: 0967-5868

Abstract

<abstract xml:lang="en" abstract-type="author" id="ab005"> <title id="st075">Abstract</title> <sec> <p id="sp0005">We aimed to evaluate the expression of the major components of microRNA biogenesis machinery including Drosha, Dicer and DiGeorge syndrome critical region gene 8 (DGCR8) in multiple sclerosis (MS) patients. The expression levels of these components in relapsing remitting multiple sclerosis (RRMS) patients were significantly up-regulated in comparison to healthy controls. DGCR8 was up-regulated 4.9 times in RRMS patients <italic>versus</italic> healthy controls, and Drosha was up-regulated 3.58 times. Additionally, the expression level of Dicer was 2.11 times higher in RRMS patients than the healthy controls. In conclusion, our results suggest that overexpression of Drosha, Dicer and DGCR8 may contribute to the pathogenesis of MS. Further investigation may introduce microRNA biogenesis machinery as MS markers and therapeutic targets.</p> </sec> </abstract>