C-Myc plays part in drug resistance mediated by bone marrow stromal cells in acute myeloid leukemia. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Xia, Bing; Tian, Chen; Guo, Shanqi; Zhang, Le; Zhao, Dandan; Qu, Fulian; Zhao, Weipeng; Wang, Yafei; Wu, Xiaoxiong; Da, Wanming; Wei, Sheng; Zhang, Yizhuo
• Is Part Of: Leukemia research. Volume 39:Issue 1(2015:Jan.)
• Page Start: 92
• Page End: 99
• Publication Date: 2015-01
• Subjects: Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2014.11.004
• Languages: English
• ISSNs: 0145-2126

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Adhesion of AML cell lines and primary AML cells to mesenchymal stromal cells (MSC) inhibited cytotoxic drug-induced apoptosis.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">c-Myc contributed to microenvironment-mediated drug resistance in AML.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">c-Myc is a potential therapeutic target for overcoming drug resistance in AML.</p> </list-item> </list> </p> </sec> </abstract>