Evaluation of methods to detect CALR mutations in myeloproliferative neoplasms. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Jones, Amy V.; Ward, Daniel; Lyon, Matthew; Leung, William; Callaway, Alison; Chase, Andrew; Dent, Carolyn L.; White, Helen E.; Drexler, Hans G.; Nangalia, Jyoti; Mattocks, Chris; Cross, Nicholas C.P.
• Is Part Of: Leukemia research. Volume 39:Issue 1(2015:Jan.)
• Page Start: 82
• Page End: 87
• Publication Date: 2015-01
• Subjects: Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2014.11.019
• Languages: English
• ISSNs: 0145-2126

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">We compared different techniques for diagnostic detection of <italic>CALR</italic> mutations.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">We identified MARIMO as an MPN/AML cell line that is <italic>CALR</italic> mutated.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Targeted NGS has the lowest limit of detection at 1% mutation burden.</p> </list-item> </list> </p> </sec> </abstract>