Robust mucosal-homing antibody-secreting B cell responses induced by intramuscular administration of adjuvanted bivalent human norovirus-like particle vaccine. Issue 4 (15th January 2015)

• Record Type: Journal Article
• Authors: Sundararajan, Aarthi; Sangster, Mark Y.; Frey, Sharon; Atmar, Robert L.; Chen, Wilbur H.; Ferreira, Jennifer; Bargatze, Robert; Mendelman, Paul M.; Treanor, John J.; Topham, David J.
• Is Part Of: Vaccine. Volume 33:Issue 4(2015)
• Page Start: 568
• Page End: 576
• Publication Date: 2015-01-15
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2014.09.073
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">GI.1/GII.4 bivalent Norovirus-like particle vaccine elicited B cell plasmablasts in peripheral blood.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">High frequencies of VLP-specific antibody secreting cells were present in peripheral blood.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Plasmablasts exhibited a strongly mucosal homing phenotype and high proportions of IgA secreting cells.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Results are consistent with recall of pre-existing cellular immune memory.</p> </list-item> </list> </p> </sec> </abstract>