Regulation of T cells by mTOR: the known knowns and the known unknowns. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Pollizzi, Kristen N.; Powell, Jonathan D.
• Is Part Of: Trends in immunology. Volume 36:Issue 1(2015)
• Page Start: 13
• Page End: 20
• Publication Date: 2015-01
• Subjects: Immunology -- Periodicals; 571.96
• DOI: 10.1016/j.it.2014.11.005
• Languages: English
• ISSNs: 1471-4906

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">mTOR has emerged as a critical integrator of cues from the immune microenvironment.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">By coordinating immunologic and metabolic programs, mTOR guides T cell fate decisions.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Mechanisms by which mTOR activity impacts T cell differentiation are not fully defined.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Contradictory findings highlight areas requiring further investigation.</p> </list-item> </list> </p> </sec> </abstract>