Antecedents and correlates of visual field deficits in children born extremely preterm. (January 2015)

• Record Type: Journal Article
• Authors: Holm, Mari; Msall, Michael E.; Skranes, Jon; Dammann, Olaf; Allred, Elizabeth; Leviton, Alan
• Is Part Of: European journal of paediatric neurology. Volume 19:Number 1(2015:Jan.)
• Page Start: 56
• Page End: 63
• Publication Date: 2015-01
• Subjects: Pediatric neurology -- Periodicals; Nervous System Diseases -- Periodicals; Child -- Periodicals; Infant -- Periodicals; Neurologie pédiatrique -- Périodiques; Pediatric neurology; Electronic journals; Periodicals; Electronic journals; 618.928
• DOI: 10.1016/j.ejpn.2014.10.002
• Languages: English
• ISSNs: 1090-3798

Abstract

<abstract xml:lang="en" abstract-type="author" id="abs0010"> <title id="sectitle0010">Abstract</title> <sec> <title id="sectitle0015">Aim</title> <p id="abspara0010">We sought to identify the antecedents and correlates of visual field deficits (VFDs) at age 2 years among infants born before the 28th week of gestation.</p> </sec> <sec> <title id="sectitle0020">Methods</title> <p id="abspara0015">The visual fields of 1023 infants were assessed by confrontation at age 2 years. We compared the ante-and postnatal characteristics and exposures of the 65 infants with a VFD to their peers who did not have a VFD. We used time-oriented logistic regression risk models to assess the associations of potential antecedents and correlates with a VFD.</p> </sec> <sec> <title id="sectitle0025">Results</title> <p id="abspara0020">In the final regression model, VFD was associated with maternal consumption of aspirin during the current pregnancy, recurring/persistent acidemia during the first 3 postnatal days, cerebral ventriculomegaly seen on neonatal ultrasound, prethreshold retinopathy of prematurity (ROP), and supplemental oxygen and ventilator dependence at 36 weeks post-menstrual age. Birth before the 27th week was also associated with increased risk, but its significance was diminished by the addition of postnatal variables.</p> </sec> <sec> <title id="sectitle0030">Conclusion</title> <p id="abspara0025">In this sample of extremely preterm born infants, antenatal as well as early and late postnatal characteristics and exposures are associated with an increased risk of having a VFD. Our study adds to our knowledge about the complex etiology of visual deficits of prematurity, and supports a multifactorial cause of these deficits.</p> </sec> </abstract>