Pregnancy and neurodevelopmental outcomes with in-utero antiepileptic agent exposure. A pilot study. (January 2015)

• Record Type: Journal Article
• Authors: Arkilo, Dimitrios; Hanna, Julie; Dickens, Deanna; Justesen, Lorna; Brunn, Jenny; Garland, Sarah; Penovich, Patricia
• Is Part Of: European journal of paediatric neurology. Volume 19:Number 1(2015:Jan.)
• Page Start: 37
• Page End: 40
• Publication Date: 2015-01
• Subjects: Pediatric neurology -- Periodicals; Nervous System Diseases -- Periodicals; Child -- Periodicals; Infant -- Periodicals; Neurologie pédiatrique -- Périodiques; Pediatric neurology; Electronic journals; Periodicals; Electronic journals; 618.928
• DOI: 10.1016/j.ejpn.2014.09.006
• Languages: English
• ISSNs: 1090-3798

Abstract

<abstract xml:lang="en" abstract-type="author" id="abs0010"> <title id="sectitle0010">Abstract</title> <sec> <title id="sectitle0010a">Objective</title> <p id="abspara0010">To assess pregnancy outcomes on women exposed to monotherapy with antiepileptic agents.</p> </sec> <sec> <title id="sectitle0015a">Methods</title> <p id="abspara0015">Questionnaires were sent to women with epilepsy in our practice who were pregnant between 2006 and 2011. 62/86 patients (72%) who responded were on monotherapy. 24 fetuses (63%) were exposed to lamotrigine, 11 (28%) to levetiracetam, 2 (5.2%) to topiramate, 1 (2.6%) to gabapentin, 17 (27%) to carbamazepine, 5 to phenytoin and 2 to valproate.</p> </sec> <sec> <title id="sectitle0020a">Results</title> <p id="abspara0020">There were 55 (88%) live births and 7 unsuccessful pregnancies (miscarriages/stillbirths). Unsuccessful pregnancies were reported in 2/24 gestations exposed to lamotrigine, 2/11 to levetiracetam and 3/17 to carbamazepine. Delayed motor development or speech delay requiring therapy and special programming was noted in 2/24 children prenatally exposed to lamotrigine, 3/17 exposed to carbamazepine and 1/2 children exposed to valproate.</p> </sec> <sec> <title id="sectitle0025a">Conclusion</title> <p id="abspara0025">Our pilot study of children exposed to antiepileptic drug monotherapy in-utero demonstrated a favorable trend for successful pregnancy outcomes and developmental trajectory.</p> </sec> </abstract>