Quantification of the effect of Lipo-PGE1 on angiogenesis. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Eo, SuRak; Kwon, Chan; Lee, HyunJic; Cho, SangHun; Kim, JinYoung; Baek, GooHyun; Yeo, JeongSeok; Lim, ChiYeon
• Is Part Of: Journal of plastic, reconstructive & aesthetic surgery. Volume 68:Issue 1(2015:Jan.)
• Page Start: 104
• Page End: 112
• Publication Date: 2015-01
• Subjects: Surgery, Plastic -- Great Britain -- Periodicals; Reconstructive Surgical Procedures -- Periodicals; Surgery, Plastic -- Great Britain -- Periodicals; 617.9505
• DOI: 10.1016/j.bjps.2014.09.035
• Languages: English
• ISSNs: 1748-6815

Abstract

<abstract xml:lang="en" abstract-type="author" id="abs0010"> <title id="sectitle0010">Summary</title> <sec> <p id="abspara0010">Fifteen rabbits were used to assess the effect of Lipo-PGE1 on neovascularization. Merocel<sup>®</sup> and Alloderm<sup>®</sup> of the same size were implanted separately under the back skin to act as matrices for vessel growth. Lipo-PGE1 was injected intravenously for 2 weeks in an experimental group of eight rabbits, and they were compared with a control group of seven untreated animals. Blood flow was measured using the <sup>99m</sup>TcO<sub>4</sub><sup>−</sup> clearance technique. The mean blood clearance halftime (<italic>T</italic><sub>1/2</sub>) and washout radioactivity were measured. Newly formed vessels were counted by CD31. The mean clearance halftime was 4005 ± 2161.3 and 13840 ± 4644.6 s in the experimental and control group, respectively, in the 1 × 2 × 1.5-cm-sized implants (<italic>p</italic> = 0.0125), and 1560 ± 1174.7 and 3405 ± 807.03 s, respectively, in the 2 × 2 × 1.5-cm-sized implants (<italic>p</italic> = 0.0413). Histological examinations revealed that the mean numbers of newly formed vessels in the experimental and control groups were 11 ± 1.58 and 7.8 ± 1.71, respectively, in the 1 × 2 × 1.5-cm-sized implants (<italic>p</italic> = 0.0501), and 20.19 ± 12.47 and 12.33 ± 3.25, respectively, in the 2 × 2 × 1.5-cm-sized implants (<italic>p</italic> = 0.02679). Lipo-PGE1 was found to be effective in promoting angiogenesis in a rabbit matrix model.</p> </sec> </abstract>